Probe sialidase substrate specificity using chemoenzymatically synthesized sialosides containing C9-modified sialic acid.
نویسندگان
چکیده
A library of α2-3- and α2-6-linked sialyl galactosides containing C9-modified sialic acids was synthesized from C6-modified mannose derivatives using an efficient one-pot three-enzyme system. These sialosides were used in a high-throughput sialidase substrate specificity assay to elucidate the importance of C9-OH in sialidase recognition.
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 27 شماره
صفحات -
تاریخ انتشار 2012